Call for position
Early Stage Researcher at Amsterdam UMC, Cancer Center Amsterdam
Who we are
T-OP – Training Network for Optimizing Adoptive T cell Therapy of Cancer is an Initial Training Network funded by the European Union. It started on March 1st 2021 and has a duration of four years. The network comprises 17 partners, from academy, industry and public authority, located in seven different countries.
T-OP aims at improving the efficacy and production of cell therapies. It will enable future experts to develop new therapeutic solutions providing them with a program of excellence.
Over the last years, immunotherapy – using a patient’s own immune system to fight tumours – has emerged as an important complement to standard treatments. The clinical implementation of immunotherapeutics has established T cells as efficient anti-cancer weapons if targeted by specific drugs. Their therapeutic utilization has recently come to a breakthrough: adoptive T cell therapy (ACT), collecting and transforming the patient’s own T cells to treat cancer.
The generation of such ACT products is a complex but ill-defined process with limited harmonization across production and clinical studies, even for the same indication. Cytokines are a key element of these products as they are responsible for the growth and differentiation of T-cells.
There is however a limited understanding as to which cytokines might lead to the best outcome on any of these steps. T-OP targets a pioneering research question: how do cytokines influence the therapeutic outcome of ACT products? T-OP brings together interdisciplinary and cross-sectorial teams spanning large and small-sized companies as well as experts in different aspects of cell therapy, immunology, protein engineering and bioinformatics.
We offer: Cutting edge research project and training with leading experts in the field of cell therapy; employment contract in full time with the benefits of the EU Marie Skłodowska-Curie program, to be started as soon as possible and ended on February 28th, 2025.
We seek: Excellent scientist with a Master’s degree or equivalent in natural sciences or related disciplines (such as medicine or pharmacy); practical skills in modern laboratory work, preferentially combined with experience in animal experiments.
Your profile: You must be within your first four years of research experience after completion of your Master's degree or equivalent; you cannot hold a doctoral degree (except medical doctor) at the time of recruitment; you cannot have spent more than 12 months within the past 36 months in the country where the position you are applying for is located (mobility rule); you must be proficient in the English language both written and spoken (proof required).
Project 3 (ESR3): Cytokine requirements for efficient expansion of peripheral blood and tumour-derived mucosal associated invariant T (MAIT) cells for ACT of cancer. In the Netherlands, Amsterdam, at Amsterdam UMC, Cancer Center Amsterdam, supervised by Tanja D. de Gruijl and Hans J. van der Vliet for the duration of two years.
The two-stage application procedure will be carried out in compliance with the Code of Conduct for Recruitment and the Charter for Researchers.
• The first stage consists of sending your documents and filling out the required information within the application portal of T-OP, by March 30th 2023 at the latest.
Please note that we will only evaluate fully completed application forms that are submitted via the application portal of T-OP before the deadline.
• Second stage: Selected candidates from the first stage will be invited for interview, possibly remotely, with the supervisor of the position for which the candidates have applied.
Criteria of selection
1. First stage of selection:
a. Eligibility check carried out by T-OP management team:
• The candidates are in the first four years* (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree (except medical doctor).
• The candidates must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation for more than 12 months in the 3 years immediately prior to his/her recruitment.
*is measured from the date when a researcher obtained the degree which would formally entitle him or her to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the researcher is recruited, irrespective of whether or not a doctorate is or was ever envisaged.
Solely the candidates that comply with the criteria of eligibility will be assessed.
b. Assessment of the application forms by the Project Leader and her team:
• Quality of education (degrees and transcript)
• Education matching to the skills required
• Quality of research experience
• Research experience matching to required skills
• Quality of language skills
• Quality of references
• General evaluation of profile based on motivations and personal skills
• Experience of Mobility (geographical, sectoral, virtual)
2. Second stage of selection:
• Quality of the presentation
• General evaluation of profile depending on motivations and personal skills
Contact for further questions: Simone Gautier, Project Manager of T-OP - firstname.lastname@example.org